Search results for " hypothesized"

showing 3 items of 3 documents

Risk Factors for Anaplastic Thyroid Carcinoma: A Case Series From a Tertiary Referral Center for Thyroid Surgery and Literature Analysis

2022

Anaplastic thyroid carcinoma (ATC) is a very rare and extremely aggressive disease with a very poor prognosis. Several risk factors have been hypothesized, but there is no clear-cut literature data on it. We reviewed the literature concerning risk factors for ATC and analyzed the institutional database from 2005 to 2022. In total, 15 papers were suitable for review, while the retrospective data collection search, conducted on our institutional database, provided 13 results. In our experience, in agreement with literature data, ATC seems to be a neoplasm peculiar to old age (in our database, mean age is 72 years), with a higher prevalence in subjects with a low level of education and a long …

Cancer ResearchOncologythyroid hypothesized surgery
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DECORIN EFFECTS ON PROTEOMIC PROFILING OF BREAST CANCER CELLS: AN UPDATED STUDY

2015

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells, among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect, the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules, the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin, belongs to the family of small leucine-rich proteoglycans (SLRP) and is involv…

The malignant carcinomas are characterized by several capabilities acquired by the neoplastic cells among which the ability to invade the extracellular matrix (ECM) and to establish a crosstalk with several ECM components. Under this respect the extracellular microenvironment is an entity extraordinarily rich of information with opposite signals. Our group has long undertaken the study of the effects of ECM molecules on the behavior of cancer cells in vitro. Among the studied molecules the decorin was found to exert a non-permissive effect on the growth and motility of the transfected tumor cells. The decorin belongs to the family of small leucine-rich proteoglycans (SLRP) and is involved physiologically in the fibrillogenesis of collagen. In the last few year a new anti-oncogenic role has been proposed for decorin1. This study aimed to implement the knowledge on the effects of ectopic decorin on breast cancer cells using as a reference point the results already achieved by our research group2 on the experimental model format. By breast cancer cell line 8701-BC and its transfected clone DEC-C2. The extension of the proteomic analysis combined with the mass spectrometry allowed to triplicate the number of identified proteins in our model. Among the newly identified proteins were members of the classes of metabolic enzymes S100 family and cell motility proteins which revealed a net decrease in the decorin transfected cells. Of considerable importance is the observation that these classes of proteins are the most involved in metastatic progression. These results confirm and reinforce the anti-oncogenic role hypothesized for decorin. The work was co-funded by the Italian 5x1000 to COBS.DECORIN
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E-portfolio e flipped classroom: un’indagine esplorativa con i futuri insegnanti di scuola primaria

2023

Il contributo intende far riflettere sul tema della formazione dei futuri insegnanti di scuola primaria, a partire dall’impiego dell’e-portfolio come dispositivo innovativo per promuovere l’acquisizione della competenza riflessiva e autovalutativa all’interno della flipped classroom. La ricerca, che ha coinvolto 154 studenti del Corso di laurea magistrale in Scienze della Formazione Primaria dell’Università degli Studi di Palermo, che frequentavano il corso di Docimologia nell’anno accademico 2020/2021, presenta i presupposti teorici, gli obiettivi e le modalità operative di un percorso che ha visto l’impiego dell’e-portfolio nella flipped per promuovere lo sviluppo delle competenze docimol…

The study aims to reflect on the training of future primary school teachers by starting from the use of the e-portfolio as an innovative tool to promote the acquisition of reflective and self-evaluation competence within the flipped classroom. The research involved 154 students of Primary Education Master’s Degree Course of the University of Palermo attending to the Docimology course during the academic year 2020/2021. This paper presents the theoretical assumptions objectives and operating methods of a path that made the use of the e-portfolio in flipped classroom to promote the development of docimological skills in higher education. It was hypothesized that the training intervention designed according to the principles of the flippmethodology and through the use of the e-portfolio would have contributed to the development of students’ self-evaluation skills during the 30 hours of the Docimology course.Settore M-PED/04 - Pedagogia Sperimentale
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